Molecular biology of the calciferol receptor (VDR) is a key factor in a great many processes that happen to be important for general homeostasis. VDRs tend to be found in a variety of cells, including monocytes, dendritic cells, macrophages, neutrophils, keratinocytes, and epithelial cells. <\/p>\n

The vitamin D receptor is a nuclear receptor that is stimulated by the vitamin D hormone. This can be a receptor that forms a heterodimer with the retinoid X receptor. The products of the vitamin D complex with the RXR results the account activation of several intracellular signaling pathways. These types of pathways produce immediate reactions independent of the transcriptional response of target genes. <\/p>\n

VDRs also are thought to mediate the effects of vitamin D on cuboid maintenance. This is maintained the correlation between bone fragments density and VDR receptor alleles in human beings. In addition , a number of VDR goal genes have been identified, which include calcium-binding aminoacids, calbindin D-9k and 25-hydroxyvitamin D3 24-hydroxylase. <\/p>\n

Many studies contain investigated the word of VDR in various areas. For instance, confocal microscopy has demonstrated VDR indivisible staining in human cortex cells. Additionally , VDR has been recognized in light matter oligodendrocytes. These studies have generated the hypothesis that calcium-dependent platelet service may be governed by rapid non-genomic effects of VDR in mitochondria. <\/p>\n

In addition to vitamin D, VDRs have been implicated in regulation of calcium homeostasis in the intestinal tract. Nevertheless , the exact device is not known. wikipedia reference<\/a> Various factors, including environmental exposures and genetic elements, may control VDR phrase. <\/p>\n","protected":false},"excerpt":{"rendered":"

Molecular biology of the calciferol receptor (VDR) is a key factor in a great many processes that happen to be important for general homeostasis. VDRs tend to be found in a variety of cells, including monocytes, dendritic cells, macrophages, neutrophils, keratinocytes, and epithelial cells. The vitamin D receptor is a nuclear receptor that is stimulated […]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/posts\/7266"}],"collection":[{"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/comments?post=7266"}],"version-history":[{"count":1,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/posts\/7266\/revisions"}],"predecessor-version":[{"id":7267,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/posts\/7266\/revisions\/7267"}],"wp:attachment":[{"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/media?parent=7266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/categories?post=7266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fraganciastudeseo.es\/wp-json\/wp\/v2\/tags?post=7266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}